Pharmaceutical Reviews( Associate Editor) The Central Nervous System (CNS), which includes the brain, is the final major unexplored area in biomedicine. The principles of the brain/CNS are substantially unknown when compared to other organs and systems, such as the heart/circulatory system. The brain is much less understood than other human organs in terms of structure-function correlations and cell-cell communication. Recently, research institutes devoted to the study of the brain have been established, informal networks of scholars such as the European Brain Council have been built, and numerous millions of dollars have been invested in research grants and biotech initiatives, but we are just now beginning to lay the groundwork.