Pharmaceutical Review ( Associate Editor) According to new studies, the risk of stroke might rise by as much as 30% within five days of exposure to air pollution. Within five days of a stroke, researchers examined 110 observational studies from around the globe that tracked when strokes occurred and the levels of common contaminants in the air. The most frequent type of stroke, an ischemic stroke, which is brought on by a blood clot going to the brain, was represented in the meta-analysis by more than 18 million cases, according to NBC. Inhaling small pieces of particulate matter irritates and inflames the lungs. According to Michael Kleinman of the Air Pollution Health Effects Laboratory at the University of California, Irvine, who was not involved in the study, this causes your immune system to go into overdrive and eventually has an impact on the cardiovascular system.
He asserted that “there is a direct connection between what happens in the lung and what happens in the heart.”

Pharmaceutical Reviews (Associate Editor) About 16.2 particles of microplastic could be inhaled by people per hour, which is the same as one credit card over the course of a week. Additionally, these microplastics tiny environmental waste produced by the breakdown of plastic products often include hazardous contaminants and poisons. Understanding how inhaled microplastics move through the respiratory system is crucial for both preventing and treating respiratory disorders since it can lead to major health hazards. To study microplastic transport and deposition in the upper airway, researchers from the University of Technology Sydney, Western Sydney University, Urmia University, Islamic Azad University, the University of Comilla, and Queensland University of Technology created a computational fluid dynamics model.
“Millions of tons of these tiny pieces of plastic have been discovered in the soil, air, and water. The density of microplastics in the air is dramatically rising, and global microplastic output is booming. Microplastics were discovered in human airways for the first time in 2022, raising concerns about serious risks to respiratory health.

Pharmaceutical Reviews (Associate Editor) The Heart Foundation is spreading this message in conjunction with the promotion of My Heart MyLife, a free online peer support community for persons with cardiovascular illness, on Friday, September 29, World Heart Day. Research, according to Healthcare Programs Manager Natalie Raffoul, has shown that patients may experience a sense of loneliness following a diagnosis of heart illness or a heart-related event.” In our own research, most patients expressed a strong desire to feel a sense of belonging to a community that understood their unique journeys,” Ms. Raffoul said. As individuals adjust to a series of abrupt changes in their health, research indicates that persons with cardiovascular disease are more prone to experience anxiety and sadness. Supporting positive mental health is important because it reduces the risk of a second heart attack for people who have this mental health burden.

Pharmaceutical Reviews (Associate Editor) Although the threat posed by antibiotic-resistant germs to human life is real, it takes a long time for new antibiotics to be developed. The solution may lie in a class of tried-and-true medications that have been used to treat cancer for years. The development of a brand-new class of antibiotics is currently underway at Linköping University in Sweden.Numerous medications and therapeutic candidates have demonstrated exceptional efficacy in eliminating germs or malignant cells. They are used extremely rarely or not at all because of the issue that they also injure the patient. They are administered straight into the circulation and distributed throughout the body when used to treat conditions like cancer. However, Linköping University researchers are currently working on a technique to deliver potent molecules in a way that is safer, which they think may create new treatment options for a number of disorders.

Pharmaceutical Review (Associate Editor) In medical research, the issue of how to live a long, healthy life is taking center stage more frequently. Scientists now argue that gaining longevity may depend on consuming the proper foods, developing healthy behaviors, and maintaining social engagement. While centuries ago individuals may have turned to finding mythical immortality-granting things like the Holy Grail, they now say that this may not be the case. You join a “special club” of centenarians when you reach your 100th birthday. Verified Source. Despite the fact that many more people today are able to live to be 100 years old, researchers estimate that the number of centenarians was quite low before 1900.

Pharmaceutical Review (Associate editor) In illnesses referred to as autoimmune diseases, immune systems attack healthy tissues. Immune system checkpoints involving B cells are being studied by researchers as potential novel therapeutic targets. A few studies have also connected vitamin D to autoimmune diseases. The immune system stops antibodies from being created that target and damage the body’s healthy tissues. Autoimmune diseases obstruct this process.The potential of a B cell-based therapy to treat these disorders is now being examined by research teams.Eric Meffre, a professor of rheumatology and immunology at Stanford University in California and a co-author of the study, believes the results offer enormous potential for the treatment of autoimmune diseases.

According to Meffre, who spoke to Medical News Today, “B cells are a type of white blood cell that aids in the defense against infections by producing antibodies, which can recognize foreign molecules and antigens, produced by pathogens, such as bacteria and viruses.” “The body’s cells produce self-antigens, which are certain antigens. This results in the immune system identifying them as foreign invaders, which causes the B cells to attack healthy tissue in an effort to eliminate the antigens, which causes autoimmune disorders. Self-reactive B cells are those that exhibit such behavior.
The central tolerance mechanism of the immune system, which prevents this, involves exposing the B cells to self-antigens while they grow in the bone marrow. “A [DNA-sensing] receptor known as TLR9 is essential for central tolerance.”

Pharmaceutical Review (Associate Editor) Synfini, a biosciences platform that speeds up the process by which pharmaceutical and other companies may design, synthesis, and commercialize compounds for medication development, has been spun out, according to a recent announcement from SRI International.
The technology integrates a variety of software and hardware technologies created by SRI over the course of a substantial, multi-year development effort. A computational synthetic planning tool, a high-throughput automated chemistry system, a flow chemistry hardware platform, and a neuro-symbolic AI molecular designer are all included in the suite. It also contains a hardware platform that can do multi-step synthesis with reliability.

Together, Chief Executive Officer Doug Donzelli and Vice President of Finance Elizabeth Miyagi co-founded the new company, Synfini Inc., with the goal of advancing the fields of pharmaceuticals, agrochemicals, and specialty chemicals by developing scalable operations for the quick synthesis and testing of specific molecules or molecular classes. It also includes Nathan Collins, Ph.D., and Peter Madrid, Ph.D., who, as chief strategy officer and head of the Applied Research group, respectively, of SRI’s Biosciences division and division of SRI, respectively, played key roles in the development of the Synfini suite at SRI.

When AI technology is paired with the Synfini platform, we have a huge possibility to significantly improve the pharmaceutical development process, which is just beginning to be seen as having an influence across so many industries.

According to new research, a balanced lifestyle that limits smoking and excessive sedentary behavior while promoting moderate alcohol use, a good diet, regular physical activity, healthy sleep, and frequent social connections lowers the risk of depression.

An international team of researchers, including those from the University of Cambridge and Fudan University, examined a variety of factors, including lifestyle choices, genetics, brain structure, and our immune and metabolic systems, in order to identify the underlying mechanisms that may explain this connection.

The World Health Organization estimates that one in 20 persons globally suffers from depression, which has a considerable negative impact on public health. There are a variety of complex elements that can contribute to the development of depression.

The researchers were able to pinpoint seven healthy lifestyle characteristics associated with a lower risk of depression by analyzing data from nearly 290,000 individuals, 13,000 of whom had depression, over the course of a nine-year period. As follows:

usage of alcohol in moderation

exercising frequently

balanced diet

adequate slumber

not smoking

Sleeping well — between seven and nine hours every night — made the biggest difference of all these variables, lowering the risk of depression, including single depressive episodes and treatment-resistant depression, by 22%.

The best defense against recurring depressive disorder was frequent social interaction, which decreased the incidence of depression by 18% overall.

Pharmaceutical Review (Associate Editor) The accuracy, effectiveness, and accessibility of medical diagnostic technologies and data are improved by connected diagnostics, which are diagnostic systems that have been digitalized to adapt and integrate with the larger health care ecosystem.

A few examples of connected diagnostics are mobile-based health applications, laboratory surveillance networks, handheld diagnostic devices with internet access, and more.

Connected diagnostics opportunities
A number of significant benefits that connected diagnostics can provide can enhance patient outcomes and fortify healthcare systems. In order to engage and empower patients as active participants in their own treatment, connected diagnostics, for instance, can be made available at both the community and facility level. They achieve this by providing patients with access to health information and data, regardless of their location in relation to a medical facility or a healthcare professional.

A crucial goal of the World Health Organization’s World Alliance for Patient Safety is to increase follow-up on test results, and healthcare professionals can play the role of data detectives in this regard. Additionally, connected diagnostics can boost the adherence to recommendations, simplify the job of healthcare professionals, and enhance the security, timeliness, accuracy, and completeness of data.