Indian subcontinent has been ruled by different empires and dynasties throughout the past. They have brought different curative skill and knowledge. Moreover, the subcontinent surrounded by variety of believes, myths’ and religions. That obviously has significantly influenced the curative philosophy and therapeutic. Hence, we have designed this study manuscript to present a prudential review of pharmaceutical resources in sub-continent. That may potentially help to
achieve the Millennium Development Goals (MDGs). Whereas, the legislative support is an important factor in health care system, and is recognized by all countries of the subcontinent. World Health Organization (WHO) is continuously supporting to develop, strengthen and modify the existing legislation to enforce the national health policies. That will help to assign the exact professional roles to pharmacy professionals instead of irrelevant, clerical and administrative work. That will help to reduce the potential risk of irrational drug usage, therapeutical error and clinical mistakes in health care system to achieve the MDGs. Hence, in conclusion, current pharmaceutical scenario needs the legislative and strategic support to assure appropriate pharmaceutical and clinical care in Indian subcontinent. It is also enviable to assign the exact scientific and professional roles to pharmacy professional instead of irrelevant managerial and clerical tasks. That will potentially reduce the irrational drug usage and poor pharmaceutical care. Otherwise serious vulnerable health problem may potentially be posed and then harbored to other parts of the world.